Eleanor Howe, founder and CEO
Diamond Age is led by Eleanor Howe, a data scientist who has been working at the cutting edge of bioinformatics for over 15 years. As founder and CEO, Howe sets the vision for Diamond Age and ensures that its clients are working closely with consultants to tackle their most important challenges.
Trained as a computational biologist, Howe founded Diamond Age based on her expertise in transcriptional profiling — a field in which she has worked since it was dominated by small-scale microarray analysis — and her deep knowledge of drug discovery and development.
Prior to founding Diamond Age, Howe served as the go-to bioinformatician in the Center for the Development of Therapeutics at the Broad Institute of MIT and Harvard, where she helped drive drug discovery projects in cancer, cardiovascular disease, and kidney disease, among others. She also worked at the Dana-Farber Cancer Institute, where she led mid- and late-stage development of the Multiexperiment Viewer – a powerful software tool for mining large genomic datasets – and at the Institute for Genomic Research in Rockville, Maryland.
Howe earned a Ph.D. bioinformatics from Oxford University under Christopher Holmes and John Quackenbush, and holds a master’s degree in cellular and molecular biology from the University of Wisconsin-Madison and a bachelor’s degree in cellular and molecular biology from the University of Michigan. You can read her published scientific work here.
Chris Friedline brings a unique combination of expertise in IT and bioinformatics to Diamond Age. In his first career, he held leadership positions in IT and systems engineering for a range of organizations including the Virginia Commonwealth University (VCU) Health System. He then became Director of Bioinformatics and IT at Granger Genetics, which used metagenomics methodologies to inform infection management, as well as other molecular tests to evaluate treatment effectiveness in acute lymphoblastic leukemia and other blood cancers.
Chris has an M.Bin in bioinformatics and a Ph.D. in integrative life sciences from VCU, where he also completed an NSF-funded postdoctoral fellowship in ecological genomics.
Somdutta Saha, consultant
Somdutta Saha is a computational biologist with expertise in structural bioinformatics and computational biology. Her interests span the translational spectrum, from early-stage drug discovery to clinical trial design, analysis, and follow-up. Having worked in both a large pharmaceutical company (GlaxoSmithKline) and a small biotech (Solid Biosciences), she brings diverse perspectives that allow her to quickly understand what Diamond Age clients need – and how to deliver it.
Somdutta holds a Ph.D. in Bioinformatics (computational chemistry) from the University of Arkansas for Medical Sciences, and a M.Sc. in bioinformatics from the West Bengal University of Technology.
Michael DeRan, consultant
Michael DeRan brings two perspectives to Diamond Age: the skills of a computational biologist and the expertise of a formally trained bench biochemist. His work ranges from transcriptional analysis (including both bulk and single-cell RNA-seq data) to selection of promising candidates from high-throughput small-molecule screens. Prior to joining Diamond Age, he worked on early drug discovery efforts in type 2 diabetes at the Broad Institute of MIT and Harvard, and on chemical biology approaches to understanding the roles of signaling pathways in cancer at Massachusetts General Hospital.
Michael holds a Ph.D. in biochemistry from the University of Rochester School of Medicine and Dentistry, and a B.S. from Saint Bonaventure University, also in biochemistry.
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