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Case Studies

Single-Cell Insights Inform Clinical Trial Strategy for FHD-286 in Myeloid Malignancies

Challenge Foghorn Therapeutics was evaluating FHD-286, a dual BRG1/BRM inhibitor, in patients with relapsed/refractory acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) as part of a multicenter Phase I study. To better understand the drug’s impact at the cellular level, the team needed high-resolution single-cell RNA sequencing (scRNA-seq) analysis of bone marrow aspirates. Given the complexity of AML… Read More »Single-Cell Insights Inform Clinical Trial Strategy for FHD-286 in Myeloid Malignancies

Customized Omics Solutions Drive Efficiency and Reduce Costs

Challenge  Both a small startup and an established therapeutics company faced the same challenge: obtaining high-quality custom omics analysis, quickly and efficiently. The startup, with limited internal resources, found that the costly, generic reports from their sequencing CRO failed to address their specific biological questions. At the larger company, the head of computational biology had… Read More »Customized Omics Solutions Drive Efficiency and Reduce Costs

Rapid Genomic Analysis Clears FDA Hurdle

Challenge A pharmaceutical company faced a critical situation when they reported a seriousadverse event (SAE) for a patient enrolled in their clinical trial. Swift action was neededto respond to the FDA’s questions, safeguard patients, and prevent disruptions to thetrial. However, addressing FDA’s questions presented a formidable challenge because itrequired extensive, non-standard genomic analyses to establish… Read More »Rapid Genomic Analysis Clears FDA Hurdle

Evaluating Emerging Technologies With Minimal Investment

  Challenge A client of Diamond Age (DA) wanted to evaluate the utility of emerging spatial transcriptomics technologies to advance their efforts in targeting treatments to specific body tissues. The client’s needs were two-fold: first, to address specific questions about their treatment in vivo, and second, to assess the technology for future use. However, the… Read More »Evaluating Emerging Technologies With Minimal Investment

Streamlining Omics Data Analysis for Faster Decision-Making

Challenge A therapeutics company struggled to use public omics datasets to guide critical portfolio decisions, such as identifying patient population sizes for different targets, evaluating opportunities for indication expansion to determine where their therapy might be most effective, and selecting the most appropriate cell lines for in vitro or PDX experiments. The datasets were scattered… Read More »Streamlining Omics Data Analysis for Faster Decision-Making

Optimized Computational Pipeline Delivers 90% Cost Savings

Challenge A large pharmaceutical company struggled with inefficiencies in their computational pipelines for high-throughput sequencing data, which took approximately 19 hours to process. This prolonged runtime reduced their bioinformatics operations’ efficiency and led to high compute resource costs. At the time of this engagement, Diamond Age (DA) had been providing bioinformatics solutions for this high-throughput sequencing group for about a year,… Read More »Optimized Computational Pipeline Delivers 90% Cost Savings

Custom Pipeline Enhances Gene Therapy Confidence

Challenge A biotechnology client focused on developing novel methods for gene therapy needed to ensure that their constructs were accurately being integrated into the correct location in the genome and not at off-target locations, a crucial factor for the safety and efficacy of gene therapies. The client was using an existing publicly-available bioinformatics pipeline that… Read More »Custom Pipeline Enhances Gene Therapy Confidence

Strategic Collaboration Removes Bottlenecks Without Additional Headcount

Challenge A high-impact bioinformatics core team within a leading pharmaceutical company,tasked with supporting multiple drug development programs across a vast R&Ddepartment, found itself grappling with a substantial challenge. The high demand fortheir services had stretched resources to their limits, resulting in a burgeoning backlog,an overwhelmed team, and delays in delivering analysis results to stakeholders. Theteam… Read More »Strategic Collaboration Removes Bottlenecks Without Additional Headcount

Advancing Crop Production Through Microbial Pan-Genome Analysis

Challenge A leading agricultural research company sought to enhance crop production by leveraging the potential of microbes that naturally coexist with plants. Their goal was to identify and eventually engineer microbial genomes to improve beneficial traits—such as enhanced nitrogen fixation or insect repellence—thereby boosting crop performance. Although the company had an in-house bioinformatics team, they… Read More »Advancing Crop Production Through Microbial Pan-Genome Analysis

Building a Custom In Silico Target Prioritization Platform

Challenge A biotech start-up that specializes in therapeutically targeting proteins with specific structural features faced the daunting task of efficiently selecting and prioritizing potential targets. The complexity of this challenge necessitated the development of a sophisticated in silico target prioritization platform. This platform had to seamlessly integrate multi-omics and disease association data, along with protein… Read More »Building a Custom In Silico Target Prioritization Platform

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