Eleanor Howe

Challenge A large pharmaceutical company struggled with inefficiencies in their computational pipelines for high-throughput sequencing data, which took approximately 19 hours to process. This prolonged runtime reduced their bioinformatics operations’ efficiency and led to high compute resource costs. At the time of this engagement, Diamond Age (DA) had been providing bioinformatics solutions for this high-throughput sequencing group for about a year,… Read More »Optimized Computational Pipeline Delivers 90% Cost Savings

Challenge A biotechnology client focused on developing novel methods for gene therapy needed to ensure that their constructs were accurately being integrated into the correct location in the genome and not at off-target locations, a crucial factor for the safety and efficacy of gene therapies. The client was using an existing publicly-available bioinformatics pipeline that… Read More »Custom Pipeline Enhances Gene Therapy Confidence

Challenge A high-impact bioinformatics core team within a leading pharmaceutical company,tasked with supporting multiple drug development programs across a vast R&Ddepartment, found itself grappling with a substantial challenge. The high demand fortheir services had stretched resources to their limits, resulting in a burgeoning backlog,an overwhelmed team, and delays in delivering analysis results to stakeholders. Theteam… Read More »Strategic Collaboration Removes Bottlenecks Without Additional Headcount

Challenge A leading agricultural research company sought to enhance crop production by leveraging the potential of microbes that naturally coexist with plants. Their goal was to identify and eventually engineer microbial genomes to improve beneficial traits—such as enhanced nitrogen fixation or insect repellence—thereby boosting crop performance. Although the company had an in-house bioinformatics team, they… Read More »Advancing Crop Production Through Microbial Pan-Genome Analysis

Challenge A biotech start-up that specializes in therapeutically targeting proteins with specific structural features faced the daunting task of efficiently selecting and prioritizing potential targets. The complexity of this challenge necessitated the development of a sophisticated in silico target prioritization platform. This platform had to seamlessly integrate multi-omics and disease association data, along with protein… Read More »Building a Custom In Silico Target Prioritization Platform

In the dynamic landscape of clinical development, Diamond Age (DA) has solidified its position as a trusted bioinformatics partner of choice, particularly with respect to the handling of valuable patient samples. The following case studies demonstrate how DA’s tailored bioinformatics solutions played a pivotal role in helping clients navigate through complex clinical trial challenges, adapt… Read More »Custom Biomarker Analysis Guides Oncology Trial Decisions