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Eleanor Howe

Getting RNA-Seq Right and Getting it Fast with GPU-Accelerated Computing

RNA-Seq analysis often seems straightforward, like just pushing a button. But to do it well, especially for finding new drugs, you need more than just a basic approach. Every study, every experiment, and every set of data is unique. Getting RNA-Seq analysis right means you need to understand biology, be good with statistics, and really dig into the… Read More »Getting RNA-Seq Right and Getting it Fast with GPU-Accelerated Computing

Single-Cell Insights Inform Clinical Trial Strategy for FHD-286 in Myeloid Malignancies

Challenge Foghorn Therapeutics was evaluating FHD-286, a dual BRG1/BRM inhibitor, in patients with relapsed/refractory acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) as part of a multicenter Phase I study. To better understand the drug’s impact at the cellular level, the team needed high-resolution single-cell RNA sequencing (scRNA-seq) analysis of bone marrow aspirates. Given the complexity of AML… Read More »Single-Cell Insights Inform Clinical Trial Strategy for FHD-286 in Myeloid Malignancies

Customized Omics Solutions Drive Efficiency and Reduce Costs

Challenge  Both a small startup and an established therapeutics company faced the same challenge: obtaining high-quality custom omics analysis, quickly and efficiently. The startup, with limited internal resources, found that the costly, generic reports from their sequencing CRO failed to address their specific biological questions. At the larger company, the head of computational biology had… Read More »Customized Omics Solutions Drive Efficiency and Reduce Costs

Your Science Runs on Open Source. Here’s Why it’s at Risk and What You Can Do.

From the smallest lab bench to the largest pharma pipeline, every discovery relies on the same invisible network of publicly funded data resources and open-source software tools. They are the launchpad for target identification, the scaffolding for experiments, and the accelerators that help companies move at the speed of need.  Imagine losing access to PubMed,… Read More »Your Science Runs on Open Source. Here’s Why it’s at Risk and What You Can Do.

When Your “Junior” Hire Needs at Least a Decade of Experience

A lot of job descriptions for junior bioinformatics roles ask for strong coding skills, deep biological insight, strategic thinking, and polished communication. These roles aim high and for very good reason. Bridging biology and computation is at the heart of modern life science research. But for early-career scientists, developing fluency across all these domains takes… Read More »When Your “Junior” Hire Needs at Least a Decade of Experience

When to Hire a Consultant vs. Build an In-House Bioinformatics Team

In today’s data-driven life sciences landscape, bioinformatics isn’t just a support function – it’s central to planning, decision-making, and competitive differentiation. Whether you’re launching your first program or managing a global portfolio, one question consistently arises: should you build an internal team or bring in external consultants? There’s no universal answer, but the right choice… Read More »When to Hire a Consultant vs. Build an In-House Bioinformatics Team

You Don’t Need AI for That

Call it snark or pragmatism, but a recent BioBuzz panel, “Leveraging AI Across the BioPharma Value Chain,” brought something rare to the AI conversation: honesty. The panelists didn’t worship at the altar of algorithms. Instead, they asked smart questions. When does AI really add value? When is it just a high-tech answer in search of… Read More »You Don’t Need AI for That

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